Hier sollte eine kurze Einführung über die Gruppe stehen.

Here you can find research profiles and new publications.

Our genome is constantly copied, modified, rearranged and maintained. We are interested in how the complex machineries are functioning that drive these biological processes.
To this end we develop new biophysical tools that allow to monitor the activity as well as conformational states of single biomolecular machines in real time. This includes so-called tweezers techniques where magnetic and photonic forces are used to probe the mechanical properties and the states of single biomolecules. We combine such measurements with singe-molecule fluorescence approaches that report on the localization and on nanoscopic conformational changes of individual molecular players. Our single-molecule measurements are complemented by physical modeling in order to understand the main working principles of biomolecular machines.
Using this methodology we investigate the physical processes that lead to DNA compaction in the nucleus of cells, decipher the mechanisms of motor enzymes that are involved in the repair of broken DNA and explore how CRISPR-Cas enzymes that currently revolutionize the field of genome engineering are recognizing their programmable targets.

Beyond understanding biomolecular machines we also try to make use of biological principles in order to fabricate artificial bioinspired nanosystems. Hereby we exploit DNA as building material to fabricate three-dimensional objects of complex shape and with designed functionality. These structures are applied in membrane biophysics as well as for the self-assembly of nanoelectronic components.

Here you can find the plan for the current semester and the materials.

Experimental Physics I - Mechanics
(BSc IPSP)

Lecture:  

Tu 11:00 - 12:30

GrHS

 

Fr 11:00 - 12:30

GrHS

Exercise: 

We 13:30 - 15:00

SR 218

 

or We 13:30 - 15:00

SR 224

 

or We 11:00 - 12:30

SR 218

Lecture materials (after login)

 

Single Molecule spectroscopy
(M.Sc. Physik & IPSP, registration via email to ralf.seidel(at)uni-leipzig.de or at the first lecture on October 23)

Lecture:  

We 11:00 - 12:30

SR 225

Practical:

t.b.a

 

Lecture materials (after login)

Team

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Kerstin Lohse

Sekretärin

Molekulare Biophysik
Institutsgebäude
Linnéstraße 5, Raum 431
04103 Leipzig

Telefon: +49 341 97-32550

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Cordula Krause

Techn. Ang. f. Lehre u. Forschung

Molekulare Biophysik
Institutsgebäude
Linnéstraße 5, Raum 423
04103 Leipzig

Telefon: +49 341 97-32592
Telefax: +49 341 97-32549

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Dr. Nicole Weizenmann

Techn. Assistentin

Molekulare Biophysik
Institutsgebäude
Linnéstraße 5, Raum 423
04103 Leipzig

Telefon: +49 341 97-32592
Telefax: +49 341 97-32549

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